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Публикации / Какво е теломери

Какво е теломери
15.11.15 11:25
ДНК „капачките” в края на хромозомите
Вземи в gLOG
Нобеловата награда за медицина през 2009 година е връчена на трима изследователи за тяхното проучване как клетъчното остаряване е свързано с теломерите (ДНК „капачките” в края на хромозомите) и теломеразата (протеинът, който отговаря за дължината и подръжката на теломерите): а именно, как по-дългите теломери и по-голямата активност на теломераза са свързани с по-дълъг клетъчен живот и как по-късите теломери и не толкова високата активност на теломераза се свързват с клетъчната смърт. Един от Нобеловите лауреати, Елизабет Блакбърн, е съавтор на тази статия, която е частично преглед, частично доклад от оригиналното проучване на авторите, и частично теоретично разсъждение, подкрепящо идеята, че медитативната практика може да забави клетъчното стареене. Д-р Блакбърн уподобява теломерите с капачетата на края на връзките за обувки, които ги предпазват от разпридане. („Теломерите и теломеразата в здраве и болест”) По аналогия, колкото по-къси или по-износени са сходните предпазни „капачки” на хромозомните нишки (от натрупващите се ефекти от клетъчното делене), толкова по-чест е случая на клетъчна смърт. Предишно изследване на авторите е направило връзка между скъсяването на теломерите и реакциите на стрес в тялото. Настоящият материал измества тази връзка една крачка по-напред, разглеждайки как определени форми на медитация могат да смекчат реакциите на стрес, които влияят на дължината на теломерите и съответно на живота на клетките. Авторите се фокусират върху стресовата възбуда в тялото и върху два вида разпознаване на стреса: „оценка за заплаха” (която усилва негативната емоционална реакция към стресора, като го окачествява като заплаха за индивида и увеличава значимостта на стресора”) и „зацикляне” (повтарящ се мисловен процес, от който негативните оценки, както и съответната реакция на стрес, се проточват, и от който човек може да изпита тревожност от самата емоционална реакция). За редуциране на деструктивите реакции на стреса, авторите се спират на осъзната медитация, описана като секуларна адаптация на традиционните будистки медитативни техники. - Теломерите са защитните краища на хромозомите, които предпазват ДНК по време на репликацията да не се съединяват с други хромозоми. Теломерните участъци се скъсяват при всеки цикъл на делене, защото не може се синтезира копие на самия край на хромозомата. Така се скъсява и самия живот на клетката, тя старее и стават податлива на болести. Всеки с раждането си получава теломери, дълги около 9000 нуклеотида. Но след определен брой цикли на митозата, клетката вече не може да се дели. Има ензим, наречен теломераза, който може да достроява и удължава теломерите, но е активна само в стволовите и в половите клетки. Хелън Блау (Helen Blau) от Станфордския университет, Факултет по медицина е основен автор на доклада за изследването, публикуван в Journal of the Federation of American Societies for Experimental Biology. "Сега сме намерили начин да се удължат човешките теломери с цели 1000 нуклеотида, което е връщане назад на вътрешния часовник на тези клетки, еквивалент на много години човешкия живот," заяви Блау в пресрелийза. Идеята да се удължат теломерите не е нова. Идеята на екипа да манипулира и РНК, включвайки указания за TERT (един от активните компоненти на теломеразата). Ефектите траят 48 часа, но тази нетрайност има предимство, защото непрекъснатото делене на клетката увеличава риска от развитие на рак. Освен това, този метод не предизвиква имунна реакция, което се е случвало при други методи. При изследванията е установено увеличаване на дължината на теломерите с 10%, кожните клетки са се размножили 28 пъти повече, отколкото нетретирани клетки, а мускулните клетки - три допълнителни пъти. Експериментите на Блау с други видове клетки продължават. Екип от учени успешно са използвали променена иРНК (информационна рибонуклеинова киселина) за да удължат теломерите в човешките клетки, което им позволява да функционират като по-млади и да се размножават по-дълго от нетретирани клетки. Това дава надежда за пациенти със заболявания, свързани с скъсени теломери, като мускулна дистрофия тип Дюшен, разказва Лиса Уинтър (Lisa Winter) от iflscience.
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